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A retrospective analysis of 635 patients who were followed after RP and experienced BCR and/or local recurrence and either received no salvage treatment (n397) or salvage RT alone (n160) within two years of BCR, showed that salvage RT was associated with a three-fold increase. Bicalutamide (150 mg) versus placebo as immediate therapy alone or as adjuvant to therapy with curative intent for early nonmetastatic prostate cancer:.3-year median followup from the Scandinavian Prostate Cancer Group Study Number. Nevertheless, all these findings have led to strong advice against systematic population-based screening in all countries, including Europe. Indeed SNB has been shown to have a sensitivity.2 for detecting men with metastases at eLND in a SR 357. Oncology (Williston Park 2007.

Chronic exposure to lhrh agonists results in the down-regulation of lhrh-receptors, suppressing LH and FSH secretion and therefore testosterone production. Aging as a marker of response in metastatic prostate cancer Treatment response in soft-tissue metastases can be assessed by morphological imaging methods (CT or MRI) using the Response Evaluation Criteria in Solid Tumours (recist) criteria. 876.Efstathiou,.A.,. Men with impaired glucose tolerance and/or diabetes should be referred for an endocrine consultation. Your son needs to stop wearing dressing immediately.

Strong Active treatment Offer surgery and radiotherapy as alternatives to AS to patients suitable for such treatments and who accept a trade-off between toxicity and prevention of disease progression. Salvage RT initiated two years after recurrence provided no significant increase in PCa-specific survival 594.Post-radiotherapy biochemical recurrence In patients experiencing PSA-recurrence after RT, PSA-DT three months, time to biochemical progression three years, biopsy GS 8-10 or clinical stage cT3b-T4 also indicate a high risk. The role of PHI, Progensa PCA3, and SelectMDX in deciding whether to take a repeat biopsy in men who had a previous negative biopsy is uncertain and probably not cost-effective 130. 5.8 months,.44,.0001). Der,.,. Are transition zone biopsies still necessary to improve prostate cancer detection? These should be performed at three, six and twelve months after treatment, then every six months until three years, and then annually.

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825.Lecouvet,.E.,. Zaro,.J.,. Role of MRI in low-risk prostate cancer: finding the wolf in sheeps clothing or the sheep in wolfs clothing? Am J Surg Pathol, 2008. 807.Aapro,.,. Stilboestrol plus adrenal suppression as salvage treatment for patients failing treatment with luteinizing hormone-releasing hormone analogues and orchidectomy. World J Urol, 2004. Active surveillance for clinically localized prostate cancer-a systematic review. In this setting, re-biopsy within six to twelve months to exclude sampling error is mandatory 496, 500 even if this could be modified in the future 501.

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Endocr Relat Cancer, 2014. 485 performed a SR to summarise the evidence regarding the effectiveness of focal therapy in localised PCa. Both acute GI and GU toxicity appeared to be predictive for corresponding late toxicity. A GS 4 should not be given based on prostate biopsies. Detection of recurrent prostate cancer after radical prostatectomy: comparison of 11C-choline PET/CT with pelvic multiparametric MR imaging with endorectal coil. However, approximately 13-38 of patients fail to achieve this goal and up to 24 of men may experience temporary testosterone surges (testosterone 50 ng/dL) during long-term treatment 459, known as the acute on-chronic effect or breakthrough response.